Clinical decision-support only. For use by licensed dental professionals. Not a substitute for professional judgment or a complete drug reference. Always verify with primary sources.
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Allergy

NSAID / aspirin hypersensitivity

Analgesic/NSAID

Drug classes to avoid

NSAIDSalicylate

Reaction signs & chairside management

  • Bronchospasm or urticaria/angioedema on exposure

    NSAID hypersensitivity is often a pseudoallergic (COX-1-mediated) reaction rather than true IgE allergy, and frequently cross-reacts across the entire NSAID class rather than being drug-specific.

    Clinical management: Avoid NSAIDs (including ibuprofen, naproxen) and aspirin for dental pain management; use acetaminophen instead, and confirm with the prescriber if opioid analgesia is being considered.

Sources

  1. Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD): a EAACI position paper. Kowalski ML, Agache I, Bavbek S, et al.. Allergy, 2019.