Clinical decision-support only. For use by licensed dental professionals. Not a substitute for professional judgment or a complete drug reference. Always verify with primary sources.
← Back to search
Medication

Amantadine

Antiparkinsonian / antiviral

Brand names: Symmetrel, Gocovri

Oral health effects

  • Xerostomia (dry mouth)

    Anticholinergic-type dry mouth.

    Clinical management: Hydration, salivary substitutes, high-fluoride caries prevention.

  • Dizziness on standing (orthostatic hypotension)

    Orthostatic hypotension is reported in 1–5% of patients; dizziness/lightheadedness in 5–10%.

    Clinical management: Raise the chair slowly at the end of the appointment and have the patient sit upright for a minute or two before standing; steady them as they get up. Ask about dizziness on standing, especially after dose changes or in older patients.

Sources

  1. A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI. Wolff A, Joshi RK, Ekström J, et al. Drugs in R&D, 2017.
  2. Amantadine prescribing information (FDA label) Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. / DailyMed, 2025.