Amphetamine / dextroamphetamine
CNS stimulant (ADHD)
Brand names: Adderall
Oral health effects
Xerostomia (dry mouth)
Dry mouth plus stimulant-related clenching; caries risk rises, especially with sugary drinks.
Clinical management: Hydration, sugar-free gum/xylitol, salivary substitutes, high-fluoride products; reinforce caries prevention.
Bruxism
Antidepressant-associated jaw clenching/grinding can occur or worsen.
Clinical management: Assess for wear; consider an occlusal guard; discuss with prescriber if severe.
Unpleasant taste (dysgeusia)
The label lists unpleasant taste alongside dry mouth among gastrointestinal adverse reactions.
Clinical management: Ask about altered or metallic taste, which can reduce appetite and oral comfort; reassure that it is drug-related and often fades. Rule out oral candidiasis or poor hygiene as contributors and encourage sugar-free options rather than sweet foods/drinks used to mask the taste.
Sources
- A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI. Wolff A, Joshi RK, Ekström J, et al. Drugs in R&D, 2017.
- Association between psychotropic medications and presence of sleep bruxism: A systematic review. Melo G, Dutra KL, Rodrigues Filho R, et al. Journal of oral rehabilitation, 2018.
- Amphetamine / dextroamphetamine prescribing information (FDA label) Bryant Ranch Prepack / DailyMed, 2024.