Clinical decision-support only. For use by licensed dental professionals. Not a substitute for professional judgment or a complete drug reference. Always verify with primary sources.
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Medication

Baclofen

Skeletal muscle relaxant (GABA-B agonist)

Brand names: Lioresal

Oral health effects

  • Xerostomia (dry mouth)

    Reduced salivary flow with elevated caries and discomfort risk.

    Clinical management: Hydration, salivary substitutes, high-fluoride caries prevention.

  • Dizziness on standing (orthostatic hypotension)

    Hypotension is reported in up to 9% of patients, alongside dizziness and drowsiness.

    Clinical management: Raise the chair slowly at the end of the appointment and have the patient sit upright for a minute or two before standing; steady them as they get up. Ask about dizziness on standing, especially after dose changes or in older patients.

Sources

  1. A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI. Wolff A, Joshi RK, Ekström J, et al. Drugs in R&D, 2017.
  2. Baclofen prescribing information (FDA label) Northwind Health Company, LLC / DailyMed, 2025.