Clinical decision-support only. For use by licensed dental professionals. Not a substitute for professional judgment or a complete drug reference. Always verify with primary sources.
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Medication

Cimetidine

H2-receptor antagonist

Brand names: Tagamet

Oral health effects

  • Dry mouth; significant drug interactions

    Mild xerostomia; a notable CYP450 enzyme inhibitor that can raise levels of other drugs (e.g., some benzodiazepines, lidocaine).

    Clinical management: Review interactions before prescribing sedatives/analgesics; manage dry mouth.

Sources

  1. A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI. Wolff A, Joshi RK, Ekström J, et al. Drugs in R&D, 2017.