Clinical decision-support only. For use by licensed dental professionals. Not a substitute for professional judgment or a complete drug reference. Always verify with primary sources.
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Medication

Digoxin

Cardiac glycoside

Brand names: Lanoxin

Oral health effects

  • Increased gag reflex / hypersalivation (toxicity)

    Excess salivation and nausea can be early signs of digoxin toxicity; a narrow therapeutic index warrants caution.

    Clinical management: Be alert to toxicity signs; avoid excessive epinephrine in local anesthetic given arrhythmia risk; consult physician.

Sources

  1. A review and guide to drug-associated oral adverse effects-Dental, salivary and neurosensory reactions. Part 1. Teoh L, Moses G, McCullough MJ. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2019.