Clinical decision-support only. For use by licensed dental professionals. Not a substitute for professional judgment or a complete drug reference. Always verify with primary sources.
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Medication

Hydralazine

Direct vasodilator (antihypertensive)

Brand names: Apresoline

Oral health effects

  • Lupus-like / lichenoid reaction

    Can induce a drug-induced lupus or lichenoid mucosal reaction with chronic use.

    Clinical management: Recognize temporal association; biopsy if uncertain; refer to physician.

Sources

  1. A review and guide to drug-associated oral adverse effects-Oral mucosal and lichenoid reactions. Part 2. Teoh L, Moses G, McCullough MJ. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2019.