Clinical decision-support only. For use by licensed dental professionals. Not a substitute for professional judgment or a complete drug reference. Always verify with primary sources.
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Medication

Lamotrigine

Mood stabilizer / anticonvulsant

Brand names: Lamictal

Oral health effects

  • Severe mucocutaneous reactions (SJS/TEN risk)

    Rarely, lamotrigine causes Stevens-Johnson syndrome / toxic epidermal necrolysis with painful oral mucosal ulceration and blistering.

    Clinical management: Treat suspected SJS/TEN as a medical emergency; urgent referral. Otherwise supportive oral care.

  • Dry mouth (xerostomia)

    Dry mouth was reported in about 6% of adults in bipolar trials (vs 4% on placebo).

    Clinical management: Ask about dry mouth; recommend frequent sips of water, sugar-free gum or xylitol lozenges, saliva substitutes, and high-fluoride toothpaste or varnish if caries risk rises.

Sources

  1. A review and guide to drug-associated oral adverse effects-Oral mucosal and lichenoid reactions. Part 2. Teoh L, Moses G, McCullough MJ. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2019.
  2. Lamotrigine prescribing information (FDA label) OWP Pharmaceuticals, Inc. / DailyMed, 2026.
  3. A review and guide to drug-associated oral adverse effects-Dental, salivary and neurosensory reactions. Part 1. Teoh L, Moses G, McCullough MJ. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2019.