Clinical decision-support only. For use by licensed dental professionals. Not a substitute for professional judgment or a complete drug reference. Always verify with primary sources.
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Medication

Letrozole

Endocrine therapy (aromatase inhibitor)

Brand names: Femara

Oral health effects

  • Reduced bone density (indirect) / dry mouth

    As with other aromatase inhibitors; frequently combined with bone-protective antiresorptives.

    Clinical management: Check for concurrent antiresorptive use (MRONJ); manage xerostomia.

Sources

  1. A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI. Wolff A, Joshi RK, Ekström J, et al. Drugs in R&D, 2017.