Metoclopramide
Prokinetic / antiemetic (dopamine antagonist)
Brand names: Reglan
Oral health effects
Tardive dyskinesia / orofacial dystonia
Dopamine blockade can cause acute dystonic reactions (including of the tongue/jaw) and, with prolonged use, tardive dyskinesia.
Mechanism: Central dopamine-receptor antagonism.
Clinical management: Recognize acute dystonia (may need anticholinergic reversal medically); document dyskinesia; refer.
Sources
- A review and guide to drug-associated oral adverse effects-Dental, salivary and neurosensory reactions. Part 1. Teoh L, Moses G, McCullough MJ. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2019.