Clinical decision-support only. For use by licensed dental professionals. Not a substitute for professional judgment or a complete drug reference. Always verify with primary sources.
← Back to search
Medication

Rasagiline

Antiparkinsonian (MAO-B inhibitor)

Brand names: Azilect

Oral health effects

  • Dry mouth / interaction cautions

    Xerostomia reported; MAO-B selectivity reduces but does not eliminate interaction concerns (sympathomimetics, meperidine).

    Clinical management: Review interactions; limit excess epinephrine if symptomatic; manage dry mouth.

  • Dizziness on standing (orthostatic hypotension)

    Orthostatic hypotension is a label warning (13% vs 9% on placebo in one trial).

    Clinical management: Raise the chair slowly at the end of the appointment and have the patient sit upright for a minute or two before standing; steady them as they get up. Ask about dizziness on standing, especially after dose changes or in older patients.

Sources

  1. A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI. Wolff A, Joshi RK, Ekström J, et al. Drugs in R&D, 2017.
  2. Rasagiline prescribing information (FDA label) Rising Pharma Holdings, Inc. / DailyMed, 2025.