Clinical decision-support only. For use by licensed dental professionals. Not a substitute for professional judgment or a complete drug reference. Always verify with primary sources.
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Medication

Tadalafil

PDE5 inhibitor

Brand names: Cialis, Adcirca

Oral health effects

  • Nitrate interaction / flushing

    Long-acting PDE5 inhibitor; dangerous interaction with nitrates and additive hypotension. Flushing and nasal congestion common.

    Clinical management: Avoid nitrate-containing products; manage hypotension risk.

Sources

  1. Adverse drug events in the oral cavity. Yuan A, Woo SB. Oral surgery, oral medicine, oral pathology and oral radiology, 2015.