Clinical decision-support only. For use by licensed dental professionals. Not a substitute for professional judgment or a complete drug reference. Always verify with primary sources.
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Medication

Tofacitinib

DMARD (JAK inhibitor)

Brand names: Xeljanz

Oral health effects

  • Increased infection / candidiasis risk & delayed healing

    JAK inhibition increases infection risk, including herpes zoster reactivation that can involve the trigeminal distribution.

    Clinical management: Monitor for fungal/viral infection; emphasize hygiene; consider antimicrobial prophylaxis per medical advice; plan atraumatic care and coordinate timing of invasive procedures.

Sources

  1. Adverse drug events in the oral cavity. Yuan A, Woo SB. Oral surgery, oral medicine, oral pathology and oral radiology, 2015.